TH5487
Product Specifications
UNSPSC Description
TH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC50 of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes[1].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/th5487.html
Purity
98.76
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(N1CCC(N(C2=CC=CC(Br)=C2N3)C3=O)CC1)NC4=CC=C(I)C=C4
Molecular Weight
541.18
References & Citations
[1]Visnes T, et al. Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science. 2018 Nov 16;362(6416):834-839.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-125276/TH5487-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-125276/TH5487-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2304947-71-3
Available Sizes
Curated Selection
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