Desmethylicaritin

Desmethylicaritin is a phytoestrogenic molecule, has inducible effect on directional differentiation of embryonic stem cells into cardiomyocytes. Desmethylicaritin also suppresses adipogenesis via Wnt/β-catenin signaling pathway[1][2].

Product Specifications

CAS Number

[28610-31-3]

UNSPSC

12352005

Target

Wnt

Type

Natural Products

Related Pathways

Stem Cell/Wnt

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/desmethylicaritin.html

Purity

99.77

Solubility

10 mM in DMSO

Smiles

O=C1C(O)=C(C2=CC=C(O)C=C2)OC3=C(C/C=C(C)\C)C(O)=CC(O)=C13

Molecular Formula

C20H18O6

Molecular Weight

354.35

References & Citations

[1]Wang XL, et al. Phytoestrogenic molecule desmethylicaritin suppressed adipogenesis via Wnt/β-catenin signaling pathway. Eur J Pharmacol. 2013 Aug 15;714 (1-3) :254-60. |[2]Zhu DY, et al. Inducible effects of icariin, icaritin, and desmethylicaritin on directional differentiation of embryonic stem cells into cardiomyocytes in vitro. Acta Pharmacol Sin. 2005 Apr;26 (4) :477-85.