PIM3-IN-1 (hydrochloride)
PIM3-IN-1 hydrochloride (Compound 19a) is an inhibitor of (PIM2/3), with the highest inhibition level being against PIM3, having an IC50 value in the nanomolar range. PIM3-IN-1 hydrochloride can be used in cancer research[1].
Product Specifications
UNSPSC
12352005
Target
Pim
Type
Reference compound
Related Pathways
JAK/STAT Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pim3-in-1-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
CNCCCN1C2=CC=CC=C2C3=C1C4=C(C5=C3C=NN5)C6=C(N4)C=CC=C6.Cl.Cl
Molecular Formula
C23H23Cl2N5
Molecular Weight
440.37
References & Citations
[1]Frazier T, et al. Synthesis, kinase inhibition and anti-leukemic activities of diversely substituted indolopyrazolocarbazoles. Eur J Med Chem. 2024;269:116352.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PIM2; PIM3
Curated Selection
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