PIM3-IN-1 (hydrochloride)

PIM3-IN-1 hydrochloride (Compound 19a) is an inhibitor of (PIM2/3), with the highest inhibition level being against PIM3, having an IC50 value in the nanomolar range. PIM3-IN-1 hydrochloride can be used in cancer research[1].

Product Specifications

UNSPSC

12352005

Target

Pim

Type

Reference compound

Related Pathways

JAK/STAT Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pim3-in-1-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

CNCCCN1C2=CC=CC=C2C3=C1C4=C(C5=C3C=NN5)C6=C(N4)C=CC=C6.Cl.Cl

Molecular Formula

C23H23Cl2N5

Molecular Weight

440.37

References & Citations

[1]Frazier T, et al. Synthesis, kinase inhibition and anti-leukemic activities of diversely substituted indolopyrazolocarbazoles. Eur J Med Chem. 2024;269:116352.