AMG 579

AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM.

Product Specifications

CAS Number

[1227067-61-9]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/AMG_579.html

Concentration

10mM

Purity

99.02

Solubility

DMSO : 41.67 mg/mL (ultrasonic)

Smiles

CC(N1CCC(C2=NC=CN=C2OC3=CC=C(C(C4=NC5=CC=CC=C5N4)=O)C=C3)CC1)=O

Molecular Formula

C25H23N5O3

Molecular Weight

441.48

References & Citations

[1]Hu E, et al. Discovery of clinical candidate 1- (4- (3- (4- (1H-benzo[d]imidazole-2-carbonyl) phenoxy) pyrazin-2-yl) piperidin-1-yl) ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) . J Med Chem. 2014 Aug 14;57 (15) :6632-41.