AMG 579
AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM.
Product Specifications
CAS Number
[1227067-61-9]
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/AMG_579.html
Concentration
10mM
Purity
99.02
Solubility
DMSO : 41.67 mg/mL (ultrasonic)
Smiles
CC(N1CCC(C2=NC=CN=C2OC3=CC=C(C(C4=NC5=CC=CC=C5N4)=O)C=C3)CC1)=O
Molecular Formula
C25H23N5O3
Molecular Weight
441.48
References & Citations
[1]Hu E, et al. Discovery of clinical candidate 1- (4- (3- (4- (1H-benzo[d]imidazole-2-carbonyl) phenoxy) pyrazin-2-yl) piperidin-1-yl) ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) . J Med Chem. 2014 Aug 14;57 (15) :6632-41.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
PDE10
Available Sizes
Curated Selection
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