PSB-10 (hydrochloride)
PSB-10 hydrochloride is a potent and selective antagonist of human adenosine A3 receptor (A3AR), with a Ki of 0.44 nM. PSB-10 hydrochloride shows more than 800-fold selectivity for hA3 over rA1, rA2A, hA1, hA2A and hA2B receptors (Ki=805, 6040, 1700, 2700, 30000 nM, respectively) . PSB-10 hydrochloride produces thermal hyperalgesia in mice[1][2].
Product Specifications
CAS Number
591771-91-4
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/psb-10-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C)C2=C(N=C(C3=CC(Cl)=CC(Cl)=C3Cl)N2)C4=N[C@H](CC)CN14.[H]Cl
Molecular Formula
C16H15Cl4N5O
Molecular Weight
435.14
References & Citations
[1]Ozola V, et, al. 2-Phenylimidazo[2,1-i]purin-5-ones: structure-activity relationships and characterization of potent and selective inverse agonists at Human A3 adenosine receptors. Bioorg Med Chem. 2003 Feb 6;11 (3) :347-56.|[2]Abo-Salem OM, et, al. Antinociceptive effects of novel A2B adenosine receptor antagonists. J Pharmacol Exp Ther. 2004 Jan;308 (1) :358-66.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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