ADX-47273

ADX-47273 is a potent, selective and brain-penetrant mGluR5 positive allosteric modulator (PAM), with an EC50 of 0.17 μM for potentiation of glutamate (50 nM) response. ADX-47273 has antipsychotic and procognitive activities[1][2].

Product Specifications

CAS Number

[851881-60-2]

UNSPSC

12352005

Hazard Statement

H301, H311, H331

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ADX-47273.html

Purity

99.94

Solubility

DMSO : ≥ 31 mg/mL|Methanol : 105.5 mg/mL (ultrasonic; warming)

Smiles

O=C(C1=CC=C(F)C=C1)N2C[C@@H](C3=NC(C4=CC=C(F)C=C4)=NO3)CCC2

Molecular Formula

C20H17F2N3O2

Molecular Weight

369.36

Precautions

H301, H311, H331

References & Citations

[1]Liu F, et al. ADX47273 [S- (4-fluoro-phenyl) -{3-[3- (4-fluoro-phenyl) -[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities. J Pharmacol Exp Ther. 2008 Dec;327 (3) :827-39.|[2]Xu J, et al. Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning. Learn Mem. 2013 Jul 18;20 (8) :438-45.|[3]Schlumberger C, et, al. Effects of a positive allosteric modulator of mGluR5 ADX47273 on conditioned avoidance response and PCP-induced hyperlocomotion in the rat as models for schizophrenia. Pharmacol Biochem Behav. 2010 Mar;95 (1) :23-30.