Nrf2 activator-10
Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent inducer for antioxidant response element (ARE) (EC50 is 2.7 μM) and an activator for Nrf2. Nrf2 activator-10 modifies Keap1, blocks Cul3-Keap1 ubiquitin ligase complex, activates the transcription of Nrf2. Nrf2 activator-10 protects cells from H2O2-induced apoptosis.
Product Specifications
CAS Number
[75483-04-4]
UNSPSC
12352005
Hazard Statement
H317
Target
Apoptosis; Keap1-Nrf2
Type
Reference compound
Related Pathways
Apoptosis; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nrf2-activator-10.html
Purity
98.65
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=C(Cl)C2=C(C=CC=C2)N(C)C1=O)OCC
Molecular Formula
C13H12ClNO3
Molecular Weight
265.69
Precautions
H317
References & Citations
[1]Hur W, et al., A small-molecule inducer of the antioxidant response element. Chem Biol. 2010 May 28;17 (5) :537-47.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Rabbit Monoclonal VE-Cadherin Antibody (048) [Alexa Fluor 594]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)