Luvadaxistat
Product Specifications
UNSPSC Description
Luvadaxistat (TAK-831) is an orally active, highly selective, potent D-amino acid oxidase (DAAO) inhibitor. Luvadaxistat inhibits oxidative deamination of D-serine via the human recombinant DAAO enzyme with an IC50 of 14 nM. Luvadaxistat significantly increases D-serine levels in the rodent brain, plasma, and cerebrospinal fluid. Luvadaxistat has the potential for schizophrenia research[1][2].
Target Antigen
Xanthine Oxidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/luvadaxistat.html
Purity
99.89
Solubility
DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C1C(O)=CC(CCC2=CC=C(C(F)(F)F)C=C2)=NN1
Molecular Weight
284.23
References & Citations
[1]Wang H, Norton J, Xu L, DeMartinis N, Sen R, Shah A, Farmer J, Lynch D. Results of a randomized double-blind study evaluating luvadaxistat in adults with Friedreich ataxia. Ann Clin Transl Neurol. 2021 Jun;8(6):1343-1352.|[2]Rosa Fradley, et al. Luvadaxistat: A Novel Potent and Selective D-Amino Acid Oxidase Inhibitor Improves Cognitive and Social Deficits in Rodent Models for Schizophrenia.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-109183/Luvadaxistat-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-109183/Luvadaxistat-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
1425511-32-5
Available Sizes
Curated Selection
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