Ro 64-5229
Ro 64-5229 is a selective, non-competitive mGlu2 antagonist. RO 64-5229 reduces the presynaptic inhibitory effect of Neuroligin 1[1].
Product Specifications
CAS Number
[246852-46-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ro-64-5229.html
Solubility
10 mM in DMSO
Smiles
ClC1=C(/C(OC2CCCCCC2)=C/N3N=CN=C3)C(Cl)=CC=C1
Molecular Formula
C17H19Cl2N3O
Molecular Weight
352.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Gjørlund MD, et al. Soluble Ectodomain of Neuroligin 1 Decreases Synaptic Activity by Activating Metabotropic Glutamate Receptor 2. Front Mol Neurosci. 2017 May 3;10:116.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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