GW-1100

GW-1100 is a selective GPR40 antagonist with a pIC50 of 6.9.

Product Specifications

CAS Number

[306974-70-9]

UNSPSC

12352005

Target

Free Fatty Acid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/gw-1100.html

Purity

97.14

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C(CC2=CN=C(N=C2)OCC)=CN(C(SCC3=CC=C(C=C3)F)=N1)C4=CC=C(C(OCC)=O)C=C4

Molecular Formula

C27H25FN4O4S

Molecular Weight

520.58

References & Citations

[1]Stoddart LA, et al. Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O- (3-[35S]thio) triphosphate binding studies reflects binding of an endogenous agonist. Mol Pharmacol. 2007 Apr;71 (|[2]Briscoe CP, et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br J Pharmacol. 2006 Jul;148 (5) :619-28.|[3]Manosalva C, et al. Cloning, identification and functional characterization of bovine free fatty acid receptor-1 (FFAR1/GPR40) in neutrophils. PLoS One. 2015 Mar 19;10 (3) :e0119715.|[4]Nakamoto K, et al. Hypothalamic GPR40 signaling activated by free long chain fatty acids suppresses CFA-induced inflammatorychronic pain. PLoS One. 2013 Dec 12;8 (12) :e81563.