What is the catalog number for Tamibarotene?

The catalog number for Tamibarotene is HY-14652.

What sizes are available for Tamibarotene?

Tamibarotene is available in the following size(s): 5 mg, 10 mg, 10 mM - 1 mL, 50 mg, 100 mg, 200 mg, 500 mg, 1 g.

How many pack sizes does Tamibarotene come in?

Tamibarotene is available in 8 different pack sizes.

Is Tamibarotene in stock?

Tamibarotene is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Tamibarotene?

Tamibarotene is manufactured by QuantiMol.

What is the estimated delivery time for Tamibarotene?

Estimated delivery time for Tamibarotene is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Tamibarotene?

The safety data sheet for Tamibarotene is available here: http://file.medchemexpress.com/batch_PDF/HY-14652/Tamibarotene-SDS-MedChemExpress.pdf.

Tamibarotene

Tamibarotene is an orally active retinoic acid receptor α (RARα) agonist, showing high selectivity over RARγ.

Product Specifications

CAS Number

94497-51-5

Product Name Alternative

Am 80

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; RAR/RXR

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Tamibarotene.html

Purity

99.94

Solubility

DMSO : 25.5 mg/mL (ultrasonic; warming)

Smiles

O=C(C1=CC=C(C=C1)C(NC2=CC=C3C(C)(CCC(C)(C3=C2)C)C)=O)O

Molecular Formula

C22H25NO3

Molecular Weight

351.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Wang X, et al. Retinoic acid receptor alpha drives cell cycle progression and is associated with increased sensitivity to retinoids in T-cell lymphoma. Oncotarget. 2017 Apr 18;8 (16) :26245-26255.|[2]Toyama T, et al. Tamibarotene Ameliorates Bleomycin-Induced Dermal Fibrosis by Modulating Phenotypes of Fibroblasts, Endothelial Cells, and Immune Cells. J Invest Dermatol. 2016 Feb;136 (2) :387-98.|[3]Jin Y, et al. Tamibarotene modulates the local immune response in experimental periodontitis. Int Immunopharmacol. 2014 Dec;23 (2) :537-45.|[4]Lv XR, et al. Synthetic retinoid Am80 up-regulates apelin expression by promoting interaction of RARα with KLF5 and Sp1 in vascular smooth muscle cells. Biochem J. 2013 Nov 15;456 (1) :35-46.|[5]Kitaoka K, et al. The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice. Neuropharmacology. 2013 Sep;72:58-65.