WSD0628
WSD0628 is a brain penetrant and potent ATM inhibitor with profound radiosensitizing effect[1].
Product Specifications
CAS Number
[2765448-96-0]
UNSPSC
12352005
Target
ATM/ATR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wsd0628.html
Purity
99.43
Solubility
10 mM in DMSO
Smiles
CN(C(N1[C@H]2C(F)(F)CN(C)CC2)=O)C3=C1C4=CC(C5=CN=C(OC)C=C5)=CC=C4N=C3
Molecular Formula
C23H23F2N5O2
Molecular Weight
439.46
References & Citations
[1]Zhiyi Xue, et al. Abstract A148: The radiosensitizing effects of the novel brain penetrant and potent ATM inhibitor WSD0628 in glioblastoma and melanoma patient derived xenografts. Mol Cancer Ther (2023) 22 (12_Supplement) : A148.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Curated Selection
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