3,6-Diaminoacridine

Proflavine is a multifunctional acridine compound. 3,6-Diaminoacridine is an acridine dye and also a DNA inserter. Proflavine is a potent broad-spectrum antibacterial agent, and its mechanism is to insert into bacterial DNA, interfering with replication and transcription, causing bacterial lysis. 3,6-Diaminoacridine is a Kir3.2 potassium channel blocker and can be used to study the neurological phenotype of Down syndrome. 3,6-Diaminoacridine can penetrate the stratum corneum of the skin and accumulate in the cell nucleus and long-term exposure may induce skin cancer or other malignant tumors[1][2][3].

Product Specifications

CAS Number

[92-62-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; DNA/RNA Synthesis; Fluorescent Dye; Potassium Channel

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/proflavine.html

Concentration

10mM

Purity

98.78

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

NC1=CC2=NC3=CC(N)=CC=C3C=C2C=C1

Molecular Formula

C13H11N3

Molecular Weight

209.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Mansour K.Gatasheh, et al. Proflavine an acridine DNA intercalating agent and strong antimicrobial possessing potential properties of carcinogen. Karbala International Journal of Modern Science. 2017 Dec, 3 (4) : 272-278. |[2]Hitoshi Kawada, et al. Isolation of proflavine as a blocker of G protein-gated inward rectifier potassium channels by a cell growth-based screening system. Neuropharmacology. 2016 Oct;109:18-28. |[3]Jiaxin Chen, et al. Determination of proflavine in rat whole blood without sample pretreatment by laser desorption postionization mass spectrometry. Anal Bioanal Chem. 2017 Apr;409 (11) :2813-2819.