Chromanol 293B

Chromanol 293B is a selective blocker of the slow delayed rectifier K+ current (IKs) with IC50 of 1-10 μM and a weak inhibitor of KATP channel. Chromanol 293B also blocks the CFTR chloride current with an IC50 of 19 μM[1].

Product Specifications

CAS Number

[163163-23-3]

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

CFTR; Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/chromanol-293b.html

Purity

99.2

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CCS(N([C@H]1C2=CC(C#N)=CC=C2OC(C)([C@@H]1O)C)C)(=O)=O

Molecular Formula

C15H20N2O4S

Molecular Weight

324.40

Precautions

H302+H312+H332

References & Citations

[1]Bachmann A, Quast U, Russ U. Chromanol 293B, a blocker of the slow delayed rectifier K+ current (IKs), inhibits the CFTR Cl- current. Naunyn Schmiedebergs Arch Pharmacol. 2001 Jun;363 (6) :590-6.