T-1101 (tosylate)
T-1101 tosylate (TAI-95 tosylate) is the tosylate salt form of T-1101. T-1101 tosylate is an orally active inhibitor for mitose regulating highly expressed oncoprotein 1 (Hec1). T-1101 tosylate blocks the interaction between Hec1 and NEK2, exhibits cytotoxicity in human liver cancer cells with GI50 of 15-70 nM. T-1101 tosylate induces apoptosis in Huh-7. T-1101 tosylate exhibits antitumor efficacy in mouse models[1].
Product Specifications
CAS Number
2250404-95-4
Product Name Alternative
TAI-95 (tosylate)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; NEKs
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/t-1101-tosylate.html
Purity
98.91
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
CC1=CC(SC2=NC=C(OCCOC)N=C2)=CC(C)=C1C3=CSC(NC(C4=CC=NC=C4)=O)=N3.CC(C=C5)=CC=C5S(=O)(O)=O
Molecular Formula
C31H31N5O6S3
Molecular Weight
665.80
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
NEK2
Available Sizes
Frequently Asked Questions
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