T-1101 (tosylate)

T-1101 tosylate (TAI-95 tosylate) is the tosylate salt form of T-1101 (HY-120356) . T-1101 tosylate is an orally active inhibitor for mitose regulating highly expressed oncoprotein 1 (Hec1) . T-1101 tosylate blocks the interaction between Hec1 and NEK2, exhibits cytotoxicity in human liver cancer cells with GI50 of 15-70 nM. T-1101 tosylate induces apoptosis in Huh-7. T-1101 tosylate exhibits antitumor efficacy in mouse models[1].

Product Specifications

CAS Number

[2250404-95-4]

Product Name Alternative

TAI-95 (tosylate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; NEKs

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/t-1101-tosylate.html

Purity

98.91

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

CC1=CC(SC2=NC=C(OCCOC)N=C2)=CC(C)=C1C3=CSC(NC(C4=CC=NC=C4)=O)=N3.CC(C=C5)=CC=C5S(=O)(O)=O

Molecular Formula

C31H31N5O6S3

Molecular Weight

665.80

Precautions

H302, H315, H319, H335

References & Citations

[1]Chuang SH, et al. Discovery of T-1101 tosylate as a first-in-class clinical candidate for Hec1/Nek2 inhibition in cancer therapy. Eur J Med Chem. 2020 Apr 1;191:112118.|[2]Huang LY, et al., Inhibition of Hec1 as a novel approach for treatment of primary liver cancer. Cancer Chemother Pharmacol. 2014 Sep;74 (3) :511-20.