Balicatib
Balicatib (AAE581) is a potent, orally active and selective cathepsin K inhibitor with IC50 values of 22, 61, 48, 2900 nM for cathepsin K, cathepsin B, cathepsin L, cathepsin S, respectively. Balicatib inhibits bone turnover, decreases bone formation rates. Balicatib has the potential for the research of osteoporosis[1][2].
Product Specifications
CAS Number
354813-19-7
Product Name Alternative
AAE581
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Cathepsin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Balicatib.html
Purity
98.25
Solubility
DMSO : 75 mg/mL (ultrasonic)
Smiles
CCCN1CCN(C2=CC=C(C(NC3(C(NCC#N)=O)CCCCC3)=O)C=C2)CC1
Molecular Formula
C23H33N5O2
Molecular Weight
411.54
Precautions
H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Cathepsin B; Cathepsin K; Cathepsin L; Cathepsin S
Available Sizes
Frequently Asked Questions
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