PROTAC TG2 degrader-2

PROTAC TG2 degrader-2 (compound 7) is a selective, competitive degrader targeting Transglutaminase 2 (TG2), with Kd > 100 μM. PROTAC TG2 degrader-2 inhibits the cell migration and decreases the level of TG2 in ovarian cancer cells. PROTAC TG2 degrader-2 can be used for ovarian cancer study[1].

Product Specifications

UNSPSC

12352005

Target

Glutaminase; PROTACs

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-tg2-degrader-2.html

Purity

99.15

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(CCOCCN(C1=CC(C)=NC(NC2=CC=C(NC(CC3=CC=CC=C3)=O)C=C2)=N1)C)N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O

Molecular Formula

C47H57N9O6S

Molecular Weight

876.08

References & Citations

[1]Valdivia A, el at. Discovery and Characterization of PROTACs Targeting Tissue Transglutaminase (TG2) . J Med Chem. 2023;66 (14) :9445-9465. doi:10.1021/acs.jmedchem.2c01859Valdivia A, Vagadia PP, Guo G, O'Brien E, Matei D, Schiltz GE. Discovery and Characterization of PROTACs Targeting Tissue Transglutaminase (TG2) . J Med Chem. 2023;66 (14) :9445-9465. doi:10.1021/acs.jmedchem.2c01859