dCeMM2
Product Specifications
UNSPSC Description
dCeMM2 (Compound 2) is a molecular glue-type degrader that targets cyclin K. dCeMM2 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex[1][2][3].
Target Antigen
CDK; Molecular Glues
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dcemm2.html
Solubility
DMSO : 41.67 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(NC1=NC=C(Cl)C=C1)CSC2=NN=C3C(NC4=C3C=CC=C4)=N2
Molecular Weight
370.82
References & Citations
[1]Mayor-Ruiz C, et al. Rational discovery of molecular glue degraders via scalable chemical profiling [published correction appears in Nat Chem Biol. 2021 Mar;17(3):361]. Nat Chem Biol. 2020;16(11):1199-1207.|[2]Jochem M, et al. Degradome analysis to identify direct protein substrates of small-molecule degraders[J]. bioRxiv, 2024: 2024.01. 28.577572.|[3]Dong G, et al. Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery. J Med Chem. 2021 Aug 12;64(15):10606-10620.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-144971/dCeMM2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-144971/dCeMM2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
296771-07-8
Available Sizes
Curated Selection
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