DCeMM2

DCeMM2 (Compound 2) is a molecular glue-type degrader that targets cyclin K. dCeMM2 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex[1][2][3].

Product Specifications

CAS Number

[296771-07-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

CDK; Molecular Glues

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dcemm2.html

Purity

99.25

Solubility

DMSO : 41.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1=NC=C(Cl)C=C1)CSC2=NN=C3C(NC4=C3C=CC=C4)=N2

Molecular Formula

C16H11ClN6OS

Molecular Weight

370.82

Precautions

H302, H315, H319

References & Citations

[1]Mayor-Ruiz C, et al. Rational discovery of molecular glue degraders via scalable chemical profiling [published correction appears in Nat Chem Biol. 2021 Mar;17 (3) :361]. Nat Chem Biol. 2020;16 (11) :1199-1207.|[2]Jochem M, et al. Degradome analysis to identify direct protein substrates of small-molecule degraders[J]. bioRxiv, 2024: 2024.01. 28.577572.|[3]Dong G, et al. Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery. J Med Chem. 2021 Aug 12;64 (15) :10606-10620.