Y-33075
Y-33075 is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM.
Product Specifications
CAS Number
199433-58-4
Product Name Alternative
Y-39983 (free base)
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Y-33075.html
Concentration
10mM
Purity
98.44
Solubility
DMSO : 50 mg/mL (ultrasonic; warming) |H2O : < 0.1 mg/mL
Smiles
O=C(NC1=C2C(NC=C2)=NC=C1)C3=CC=C(C=C3)[C@H](N)C
Molecular Formula
C16H16N4O
Molecular Weight
280.33
Precautions
H315, H319, H320
References & Citations
[1]Hideki Tokushige, et al. Effects of Topical Administration of Y-39983, a Selective Rho-Associated Protein Kinase Inhibitor, on Ocular Tissues in Rabbits and Monkeys Invest. Ophthalmol. Vis. Sci. July 2007 vol. 48no. 7 3216-3222|[2]Tokushige H, et al. Effects of Y-39983, a selective Rho-associated protein kinase inhibitor, on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats. Curr Eye Res. 2011 Oct;36 (10) :964-70.|[3]Watabe H, et al. Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries.Jpn J Ophthalmol. 2011 Jul;55 (4) :411-7. Epub 2011 Jun 11.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
ROCK
Citation 01
Acta Neuropathol Commun. 2024 Sep 14;12 (1) :150.|bioRxiv. 2025 June 03.|Cell Death Dis. 2024 Dec 26;15 (12) :932.|Cells. 2024 Nov 18;13 (22) :1907.|J Cell Physiol. 2021 Dec;236 (12) :8226-8238.|Patent. US20170349879A1.|PLoS One. 2023 Jan 31;18 (1) :e0270288.|Stem Cell Rep. 2020 Jan 14;14 (1) :49-59.|Adv Sci (Weinh) . 2022 May;9 (13) :e2104682.|Cell. 2018 Jul 26;174 (3) :636-648.e18.|Harvard Medical School LINCS LIBRARY|J Adv Res. 2024 Sep:63:117-128.|Nat Commun. 2020 Jan 3;11 (1) :88.|Neurotox Res. 2013 Apr;23 (3) :238-48.|Science. 2017 Dec 1;358 (6367) :eaan4368.
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