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Nav1.8-IN-11

Nav1.8-IN-11 (Example 1) is a Nav1.8 channel inhibitor with a IC50 value of 0.1 nM. Nav1.8-IN-11 can be used in the study of pain disorders[1].

Product Specifications

CAS Number

2990578-70-4

UNSPSC

12352005

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nav1-8-in-11.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(C=C(C(F)(F)F)C(Cl)=C1C)OC2=CC=C(C3=C2CCC3)F)NC4=CC=C[N+]([O-])=C4

Molecular Formula

C23H17ClF4N2O3

Molecular Weight

480.84

References & Citations

[1]Xuejun Zhang, et al. Nav1.8 inhibitor and use thereof. WO2023186102A1. 2023-10-05.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Nav1.8

Frequently Asked Questions

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