Etravirine

Etravirine (R165335; TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

Product Specifications

CAS Number

[269055-15-4]

Product Name Alternative

R165335; TMC125

UNSPSC

12352005

Hazard Statement

H302, H413

Target

HIV; Reverse Transcriptase

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/etravirine.html

Purity

99.07

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

N#CC1=CC(C)=C(C(C)=C1)OC2=NC(NC3=CC=C(C=C3)C#N)=NC(N)=C2Br

Molecular Formula

C20H15BrN6O

Molecular Weight

435.28

Precautions

H302, H413

References & Citations

[1]Andries, K., et al. TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1. Antimicrob Agents Chemother, 2004. 48 (12) : p. 468|[2]Lazzarin, A., et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet, 2007. 370 (9581) : p. 39-48.