Etravirine
Etravirine (R165335; TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.
Product Specifications
CAS Number
269055-15-4
Product Name Alternative
R165335; TMC125
UNSPSC
12352005
Hazard Statement
H302, H413
Target
HIV; Reverse Transcriptase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/etravirine.html
Purity
99.07
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
N#CC1=CC(C)=C(C(C)=C1)OC2=NC(NC3=CC=C(C=C3)C#N)=NC(N)=C2Br
Molecular Formula
C20H15BrN6O
Molecular Weight
435.28
Precautions
H302, H413
References & Citations
[1]Andries, K., et al. TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1. Antimicrob Agents Chemother, 2004. 48 (12) : p. 468|[2]Lazzarin, A., et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet, 2007. 370 (9581) : p. 39-48.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
HIV-1; HIV-2
Available Sizes
Frequently Asked Questions
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