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Galanin Receptor Ligand M35 (TFA)

Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of galanin receptor (Kd=0.1 nM) . Galanin Receptor Ligand M35 TFA exerts a Ki values of 0.11 and 2.0 nM for human galanin receptor type 1 and 2, respectively[1][2].

Product Specifications

UNSPSC

12352209

Target

Neuropeptide Y Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/galanin-receptor-ligand-m35-tfa.html

Solubility

10 mM in DMSO

Smiles

OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(NCC(N2[C@@H](CCC2)C(N3[C@@H](CCC3)C(N4[C@@H](CCC4)C(NCC(N[C@H](C(N[C@@H](CO)C(N5[C@@H](CCC5)C(N[C@H](C(N[C@H](C(N)=O)CCCNC(N)=N)=O)CC6=CC=CC=C6)=O)=O)=O)CC7=CC=CC=C7)=O)=O)=O)=O)=O)=O)=O)=O)NC(CNC([C@H](C)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@H]([C@H](O)C)NC([C@@H](NC(CN)=O)CC8=CNC9=CC=CC=C89)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O

Molecular Formula

C107H153N27O26.xC2HF3O2

Molecular Weight

2233.60 (free base)

References & Citations

[1]Kask K, et al. Binding and agonist/antagonist actions of M35, galanin (1-13) -bradykinin (2-9) amide chimeric peptide, in Rin m 5F insulinoma cells. Regul Pept. 1995 Nov 10;59 (3) :341-8.|[2]Webling KE, et al. Galanin receptors and ligands. Front Endocrinol (Lausanne) . 2012 Dec 7;3:146.|[3]Ogren SO, et al. Evidence for a role of the neuropeptide galanin in spatial learning. Neuroscience. 1992 Nov;51 (1) :1-5.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Frequently Asked Questions

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