(R)-Bromoenol lactone-d7
Product Specifications
UNSPSC Description
(R)-Bromoenol lactone-d7 ((R,E)-Bromoenol lactone-d7) is deuterium labeled (R)-Bromoenol lactone. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 μM[1][2].
Target Antigen
Isotope-Labeled Compounds; Phospholipase
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease;Others
Field of Research
Others
Smiles
[2H]C1=C(C([2H])=C2C(C([2H])=C(C([2H])=C2[C@@]3(C(O/C(CC3)=C/Br)=O)[H])[2H])=C1[2H])[2H]
Molecular Weight
324.22
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Jenkins CM, et al. Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPLA2s. J Biol Chem. 2002 Sep 6;277(36):32807-14.
Shipping Conditions
Room temperature
Clinical Information
Phase 1
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6163841-01 0.1 mL
GCLM (Glutamate-Cysteine Ligase, modifier Subunit, GLCLR) (AP)
Ask
View Details MBS6163841-02 5x 0.1 mL
GCLM (Glutamate-Cysteine Ligase, modifier Subunit, GLCLR) (AP)
Ask
View Details 