(R) -Bromoenol lactone-d7

(R) -Bromoenol lactone-d7 ((R, E) -Bromoenol lactone-d7) is deuterium labeled (R) -Bromoenol lactone. (R) -Bromoenol lactone ((R) -BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ) . (R) -BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 μM[1][2].

Product Specifications

Product Name Alternative

(R, E) -Bromoenol lactone-d7

UNSPSC

12352005

Target

Isotope-Labeled Compounds; Phospholipase

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Others

Smiles

[2H]C1=C(C([2H])=C2C(C([2H])=C(C([2H])=C2[C@@]3(C(O/C(CC3)=C/Br)=O)[H])[2H])=C1[2H])[2H]

Molecular Formula

C16H6D7BrO2

Molecular Weight

324.22

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Jenkins CM, et al. Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPLA2s. J Biol Chem. 2002 Sep 6;277 (36) :32807-14.