(R) -Bromoenol lactone-d7
(R) -Bromoenol lactone-d7 ((R, E) -Bromoenol lactone-d7) is deuterium labeled (R) -Bromoenol lactone. (R) -Bromoenol lactone ((R) -BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ) . (R) -BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 μM[1][2].
Product Specifications
Product Name Alternative
(R, E) -Bromoenol lactone-d7
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Phospholipase
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Others
Smiles
[2H]C1=C(C([2H])=C2C(C([2H])=C(C([2H])=C2[C@@]3(C(O/C(CC3)=C/Br)=O)[H])[2H])=C1[2H])[2H]
Molecular Formula
C16H6D7BrO2
Molecular Weight
324.22
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Jenkins CM, et al. Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPLA2s. J Biol Chem. 2002 Sep 6;277 (36) :32807-14.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
Phase 1
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