Lib2-1

Lib2-1, a macrocyclic peptide, is an IL-17C/IL-17RE interaction inhibitor. Lib2-1 can be used for autoimmune and inflammatory diseases research[1].

Product Specifications

CAS Number

[2983116-47-6]

UNSPSC

12352209

Target

Interleukin Related

Type

Peptides

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/lib2-1.html

Purity

99.63

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC2=CNC=N2)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CC4=CC=C(C=C4)O)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CC5=CC=C(C=C5)O)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(NC6)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CSC[C@@H](C(NCC(N)=O)=O)NC6=O

Molecular Formula

C81H108N18O23S

Molecular Weight

1733.90

References & Citations

[1]Silong Zhai, et al. PepScaf: Harnessing Machine Learning with In Vitro Selection toward De Novo Macrocyclic Peptides against IL-17C/IL-17RE Interaction. J Med Chem. 2023 Aug 24;66 (16) :11187-11200.