HAMA Blocking Reagent (Affinity Purified)

<strong>HAMA Blocking Reagent</strong>_x000D_ <table width="452">_x000D_ <tbody>_x000D_ <tr>_x000D_ <td><strong>Catalog #</strong></td>_x000D_ <td>A2010010</td>_x000D_ </tr>_x000D_ <tr>_x000D_ <td><strong>Size</strong></td>_x000D_ <td>10 mg</td>_x000D_ </tr>_x000D_ <tr>_x000D_ <td><strong>Other Names</strong></td>_x000D_ <td>Heterophilic Immunoglobulin Blocking Reagent</td>_x000D_ </tr>_x000D_ <tr>_x000D_ <td><strong>Concentration</strong></td>_x000D_ <td>2 mg/mL</td>_x000D_ </tr>_x000D_ <tr>_x000D_ <td><strong>Purity</strong></td>_x000D_ <td>Affinity purified</td>_x000D_ </tr>_x000D_ <tr>_x000D_ <td><strong>Storage</strong></td>_x000D_ <td>2-8°C (short term). -20°C (long term). Avoid repeated freeze-thaw.</td>_x000D_ </tr>_x000D_ <tr>_x000D_ <td><strong>Supplied as</strong></td>_x000D_ <td>Liquid solution</td>_x000D_ </tr>_x000D_ <tr>_x000D_ <td><strong>Buffer</strong></td>_x000D_ <td>PBS 1x</td>_x000D_ </tr>_x000D_ <tr>_x000D_ <td><strong>Keywords</strong></td>_x000D_ <td>HAMA</td>_x000D_ </tr>_x000D_ </tbody>_x000D_ </table>_x000D_ &nbsp;_x000D_ _x000D_ <strong>About HAMA</strong>_x000D_ _x000D_ For decades, immunoassays have relied heavily on mouse antibodies for the detection of various analytes. The accuracy of these assays can, however, suffer dramatically when patient samples contains human anti-mouse antibodies. Indeed, HAMA are often associated with inaccurate results and false positives because they can bind to both capture and detection antibodies and can generate non-specific immunoassay signals. This so-called HAMA problem is especially noticeable in patients receiving mouse antibodies therapies. Assessing the tolerance of an immunoassay to HAMA is a corner stone in assay development._x000D_ _x000D_ <strong>References Related to HAMA Blocking Reagent_x000D_ </strong>_x000D_ <ul>_x000D_ <li>Reinsberg J. (1996). Different efficacy of various blocking reagents to eliminate interferences by human antimouse antibodies with a two-site immunoassay. <em><span role="menubar">Clin Biochem.</span></em> 1996 Apr;29(2):145-8.</li>_x000D_ <li>Bolstad N, Warren DJ, Nustad K. Heterophilic antibody interference in immunometric assays. <em><span class="jrnl" title="Best practice &amp; research. Clinical endocrinology &amp; metabolism">Best Pract Res Clin Endocrinol Metab</span></em>. 2013 Oct;27(5):647-61.</li>_x000D_ <li>Lippi G, Aloe R, Meschi T, Borghi L, Cervellin G. Interference from heterophilic antibodies in troponin testing. Case report and systematic review of the literature. <em><span class="jrnl" title="Clinica chimica acta; international journal of clinical chemistry">Clin Chim Acta</span></em>. 2013 Nov 15;426:79-84.</li>_x000D_ <li>Kawasaki H, Suzuki T, Ito K, Takahara T, Goto-Inoue N, Setou M, Sakata K, Ishida N. Minos-insertion mutant of the Drosophila GBA gene homologue showed abnormal phenotypes of climbing ability, sleep and life span with accumulation of hydroxy-glucocerebroside. <span class="jrnl" title="Gene">Gene</span>. 2017 May 30;614:49-55.</li>_x000D_ <li>Hull B. Aberrantly elevated TSH level due to human anti-mouse antibodies (HAMA) interference with thyrotropin assay. <a href="https://www.ncbi.nlm.nih.gov/pubmed/23270080"><span class="jrnl" title="Journal of the South Carolina Medical Association (1975)">J S C Med Assoc</span>.</a> 2012 Feb;108(1):12-3.</li>_x000D_ <li>Degn SE, Andersen SH, Jensen L, Thiel S, Jensenius JC. Assay interference caused by antibodies reacting with rat kappa light-chain in human sera. <span class="jrnl" title="Journal of immunological methods">J Immunol Methods</span>. 2011 Sep 30;372(1-2):204-8.</li>_x000D_ </ul>_x000D_ <h4><strong>All Interference Products Brochure_x000D_ </strong></h4>_x000D_ <a href="https://moleculardepot.com/wp-content/uploads/2022/05/MKT-003-Interference-Testing-Brochure-Rev.-B.pdf"><img class="alignnone wp-image-233791479" src="https://moleculardepot.com/wp-content/uploads/2020/08/Interference-Testing-Brochure-Picture-243x300.png" alt="Interference Testing Brochure" width="252" height="311" /></a>_x000D_ <h4><strong>Related products</strong></h4>_x000D_ https://moleculardepot.com/product/high-hama-serum/_x000D_ _x000D_ https://moleculardepot.com/product/hama-interference-kit-for-assay-validation/