Cytochalasin A

Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives[1][2].

Product Specifications

CAS Number

[14110-64-6]

UNSPSC

12352005

Hazard Statement

H300, H310, H330, H361

Target

Fungal; HIV Protease

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/cytochalasin-a.html

Purity

99.61

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@H]([C@@]([C@@]12[C@](/C=C/C[C@H](C)CCCC(/C=C/C(O1)=O)=O)([H])[C@@H]3O)([H])[C@@H](NC2=O)CC4=CC=CC=C4)C3=C

Molecular Formula

C29H35NO5

Molecular Weight

477.59

Precautions

H300, H310, H330, H361

References & Citations

[1]Kerman K, et al. An electrochemical approach for the detection of HIV-1 protease. Chem Commun (Camb) . 2007 Oct 7; (37) :3829-31.|[2]Antonio Bottalico, et al. Cytochalasins: Structure-activity relationships. Phytochemistry Volume 29, Issue 1, 1990.