NS1-IN-1
NS1-IN-1 (compound 3) is a potent NS1 inhibitor. NS1 is a major influenza A virus virulence factor that inhibits host gene expression. NS1-IN-1 decreases viral protein levels, contributing to the reduction of virus replication. NS1-IN-1 shows antiviral activity by repressing the activity of mTORC1 in a TSC1-TSC2-dependent manner[1].
Product Specifications
CAS Number
[181373-35-3]
UNSPSC
12352005
Hazard Statement
H302
Target
Influenza Virus
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ns1-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(O)CCCCCN(C(C1=CC=C(N2CCCCC2)C3=CC=CC4=C13)=O)C4=O
Molecular Formula
C23H26N2O4
Molecular Weight
394.46
Precautions
P264-P270-P330-P501
References & Citations
[1]Miguel A Mata, et al. Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor. Nat Chem Biol. 2011 Sep 11;7 (10) :712-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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