NS1-IN-1

NS1-IN-1 (compound 3) is a potent NS1 inhibitor. NS1 is a major influenza A virus virulence factor that inhibits host gene expression. NS1-IN-1 decreases viral protein levels, contributing to the reduction of virus replication. NS1-IN-1 shows antiviral activity by repressing the activity of mTORC1 in a TSC1-TSC2-dependent manner[1].

Product Specifications

CAS Number

[181373-35-3]

UNSPSC

12352005

Hazard Statement

H302

Target

Influenza Virus

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ns1-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(O)CCCCCN(C(C1=CC=C(N2CCCCC2)C3=CC=CC4=C13)=O)C4=O

Molecular Formula

C23H26N2O4

Molecular Weight

394.46

Precautions

P264-P270-P330-P501

References & Citations

[1]Miguel A Mata, et al. Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor. Nat Chem Biol. 2011 Sep 11;7 (10) :712-9.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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