Sertraline (hydrochloride)

Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive[1][2].

Product Specifications

CAS Number

[79559-97-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Serotonin Transporter

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/sertraline-hydrochloride.html

Purity

99.96

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 2.86 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CN[C@H]1CC[C@@H](C2=CC=C(Cl)C(Cl)=C2)C3=C1C=CC=C3.Cl

Molecular Formula

C17H18Cl3N

Molecular Weight

342.69

Precautions

H302, H315, H319, H335

References & Citations

[1]Murdoch D, et al. Sertraline. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depression and obsessive-compulsive disorder. Drugs. 1992 Oct;44 (4) :604-24.|[2]Koe BK. Preclinical pharmacology of sertraline: a potent and specific inhibitor of serotonin reuptake. J Clin Psychiatry. 1990 Dec;51 Suppl B:13-7.|[3]Xiang X, et, al. Anti-depressive Effect of Arctiin by Attenuating Neuroinflammation via HMGB1/TLR4- And TNF-α/TNFR1-mediated NF-κB Activation. ACS Chem Neurosci. 2020 Jul 1.|[4]Lei M, et, al. Sex Differences in Antidepressant Effect of Sertraline in Transgenic Mouse Models. Front Cell Neurosci. 2019 Feb 1; 13:24.