KCC-07
KCC-07 is a potent and brain-penetrant MBD2 (methyl-CpG-binding domain protein 2) inhibitor. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. Anticancer activity[1].
Product Specifications
CAS Number
315702-75-1
UNSPSC
12352005
Hazard Statement
H302, H319
Target
DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kcc-07.html
Purity
99.97
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC1=CC=CC(NC2=NC(C3=NC=CC=C3)=CS2)=C1
Molecular Formula
C14H11N3OS
Molecular Weight
269.32
Precautions
H302, H319
References & Citations
[1]Dan Zhu, et al. BAI1 Suppresses Medulloblastoma Formation by Protecting p53 From Mdm2-Mediated Degradation. Cancer Cell. 2018 Jun 11;33 (6) :1004-1016.e5.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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