KCC-07

KCC-07 is a potent and brain-penetrant MBD2 (methyl-CpG-binding domain protein 2) inhibitor. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. Anticancer activity[1].

Product Specifications

CAS Number

[315702-75-1]

UNSPSC

12352005

Hazard Statement

H302, H319

Target

DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kcc-07.html

Purity

99.97

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC1=CC=CC(NC2=NC(C3=NC=CC=C3)=CS2)=C1

Molecular Formula

C14H11N3OS

Molecular Weight

269.32

Precautions

H302, H319

References & Citations

[1]Dan Zhu, et al. BAI1 Suppresses Medulloblastoma Formation by Protecting p53 From Mdm2-Mediated Degradation. Cancer Cell. 2018 Jun 11;33 (6) :1004-1016.e5.