MK-7246

MK-7246 is a potent and selective CRTH2 antagonist with a Ki of 2.5±0.5 nM.

Product Specifications

CAS Number

[1218918-62-7]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/MK-7246.html

Purity

99.63

Solubility

DMSO : 300 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)CC1=C(CC[C@@H](N(S(=O)(C2=CC=C(F)C=C2)=O)C)C3)N3C4=C1C=CC=C4

Molecular Formula

C21H21FN2O4S

Molecular Weight

416.47

Precautions

H315, H319, H335

References & Citations

[1]Gervais FG, et al. Pharmacological characterization of MK-7246, a potent and selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells) antagonist. Mol Pharmacol. 2011 Jan;79 (1) :69-76.|[2]Gil MA, et al. Anti-inflammatory actions of Chemoattractant Receptor-homologous molecule expressed on Th2 by the antagonist MK-7246 in a novel rat model of Alternaria alternata elicited pulmonary inflammation. Eur J Pharmacol. 2014 Nov 15;743:106-16.