MK-7246
MK-7246 is a potent and selective CRTH2 antagonist with a Ki of 2.5±0.5 nM.
Product Specifications
CAS Number
1218918-62-7
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/MK-7246.html
Purity
99.63
Solubility
DMSO : 300 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)CC1=C(CC[C@@H](N(S(=O)(C2=CC=C(F)C=C2)=O)C)C3)N3C4=C1C=CC=C4
Molecular Formula
C21H21FN2O4S
Molecular Weight
416.47
Precautions
H315, H319, H335
References & Citations
[1]Gervais FG, et al. Pharmacological characterization of MK-7246, a potent and selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells) antagonist. Mol Pharmacol. 2011 Jan;79 (1) :69-76.|[2]Gil MA, et al. Anti-inflammatory actions of Chemoattractant Receptor-homologous molecule expressed on Th2 by the antagonist MK-7246 in a novel rat model of Alternaria alternata elicited pulmonary inflammation. Eur J Pharmacol. 2014 Nov 15;743:106-16.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
DP; EP; TXA2/TP
Available Sizes
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