HIV-1 inhibitor-74
HIV-1 inhibitor-74 (compound 10c) is a potent HIV-1 inhibitor with an EC50 value of 0.0047 µM for HIV-1 IIIB. HIV-1 inhibitor-74 shows cytotoxicity. HIV-1 inhibitor-74 inhibits WT HIV-1 RT activity with an IC50 value of 0.134 µM. HIV-1 inhibitor-74 shows broad-spectrum anti HIV-1 activity[1].
Product Specifications
UNSPSC
12352005
Target
HIV
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/hiv-1-inhibitor-74.html
Smiles
N#C/C=C/C1=CC(C)=C(OC2=C(C=CS3)C3=NC(NC4CCN(CC5=CN(CC(NC)=O)N=N5)CC4)=N2)C(C)=C1
Molecular Formula
C28H31N9O2S
Molecular Weight
557.67
References & Citations
[1]Jing L, et al. Discovery of potent HIV-1 NNRTIs by CuAAC click-chemistry-based miniaturized synthesis, rapid screening and structure optimization. Eur J Med Chem. 2024 Nov 5;277:116772.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1
Frequently Asked Questions
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