QS11

QS11 is an inhibitor of ARFGAP1 (ADP-ribosylation factor GTPase-activating protein 1), with an EC50 of 1.5 μM. QS11 activates Wnt/β-catenin signaling through an effect on protein trafficking. QS11 inhibits migration of ARFGAP overexpressing breast cancer cells[1].

Product Specifications

CAS Number

[944328-88-5]

UNSPSC

12352005

Hazard Statement

H317, H319

Target

Arf Family GTPase; Wnt; β-catenin

Type

Reference compound

Related Pathways

GPCR/G Protein; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/QS11.html

Purity

99.10

Solubility

DMSO : ≥ 100 mg/mL

Smiles

OC[C@H](CC1=CC=CC=C1)NC2=C3C(N(CC4=CC=C(C5=CC=CC=C5)C=C4)C=N3)=NC(OC6=CC=C(CCC7)C7=C6)=N2

Molecular Formula

C36H33N5O2

Molecular Weight

567.68

Precautions

H317, H319

References & Citations

[1]Zhang Q, et al. Small-molecule synergist of the Wnt/beta-catenin signaling pathway. Proc Natl Acad Sci U S A. 2007 May 1;104 (18) :7444-8.|[2]Manish K. Singh, et al. Structure-activity Relationship Studies of QS11, a Small Molecule Wnt Synergistic Agonist. Bioorg Med Chem Lett. 2015 Nov 1; 25 (21) : 4838–4842.