QS11
QS11 is an inhibitor of ARFGAP1 (ADP-ribosylation factor GTPase-activating protein 1), with an EC50 of 1.5 μM. QS11 activates Wnt/β-catenin signaling through an effect on protein trafficking. QS11 inhibits migration of ARFGAP overexpressing breast cancer cells[1].
Product Specifications
CAS Number
944328-88-5
UNSPSC
12352005
Hazard Statement
H317, H319
Target
Arf Family GTPase; Wnt; β-catenin
Type
Reference compound
Related Pathways
GPCR/G Protein; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/QS11.html
Purity
99.10
Solubility
DMSO : ≥ 100 mg/mL
Smiles
OC[C@H](CC1=CC=CC=C1)NC2=C3C(N(CC4=CC=C(C5=CC=CC=C5)C=C4)C=N3)=NC(OC6=CC=C(CCC7)C7=C6)=N2
Molecular Formula
C36H33N5O2
Molecular Weight
567.68
Precautions
H317, H319
References & Citations
[1]Zhang Q, et al. Small-molecule synergist of the Wnt/beta-catenin signaling pathway. Proc Natl Acad Sci U S A. 2007 May 1;104 (18) :7444-8.|[2]Manish K. Singh, et al. Structure-activity Relationship Studies of QS11, a Small Molecule Wnt Synergistic Agonist. Bioorg Med Chem Lett. 2015 Nov 1; 25 (21) : 4838–4842.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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