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Robatumumab

Robatumumab (Sch 717454) is an anti-human IGF-1R (insulin-like growth factor receptor-1) antibody. Robatumumab shows anti-tumor activity and anti-proliferative activity to cancer cells. Robatumumab can be used in osteosarcoma and Ewing sarcoma research[1][2].

Product Specifications

CAS Number

[934235-44-6]

Product Name Alternative

Sch 717454; 19D12

UNSPSC

12352203

Target

IGF-1R

Type

Inhibitory Antibodies

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/robatumumab.html

Purity

99.90

Solubility

10 mM in DMSO

Smiles

[Robatumumab]

Molecular Weight

(146.36 kDa)

References & Citations

[1]Anderson PM, et al. A phase II study of clinical activity of SCH 717454 (robatumumab) in patients with relapsed osteosarcoma and Ewing sarcoma. Pediatr Blood Cancer. 2016 Oct;63 (10) :1761-70.|[2]Wang Y, et al. A fully human insulin-like growth factor-I receptor antibody SCH 717454 (Robatumumab) has antitumor activity as a single agent and in combination with cytotoxics in pediatric tumor xenografts. Mol Cancer Ther. 2010 Feb;9 (2) :410-8.

Shipping Conditions

Dry Ice

Storage Conditions

Store at -80°C for 2 years

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-P99218/Robatumumab-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-P99218/Robatumumab-SDS-MedChemExpress.pdf

Scientific Category

Inhibitory Antibodies

Clinical Information

Phase 2

Available Sizes

Curated Selection

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