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CK-666

CK-666 is a cell-permeable actin-related protein Arp2/3 complex inhibitor (IC50=12 μM) . CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation[1][2].

Product Specifications

CAS Number

442633-00-3

UNSPSC

12352005

Hazard Statement

H302

Target

Arp2/3 Complex; HIV

Type

Reference compound

Related Pathways

Anti-infection; Cytoskeleton

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/ck-666.html

Purity

99.95

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(NCCC1=C(C)NC2=C1C=CC=C2)C3=CC=CC=C3F

Molecular Formula

C18H17FN2O

Molecular Weight

296.34

Precautions

H302

References & Citations

+

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HIV-1

Available Sizes

Frequently Asked Questions

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