CK-666
CK-666 is a cell-permeable actin-related protein Arp2/3 complex inhibitor (IC50=12 μM) . CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation[1][2].
Product Specifications
CAS Number
[442633-00-3]
UNSPSC
12352005
Hazard Statement
H302
Target
Arp2/3 Complex; HIV
Type
Reference compound
Related Pathways
Anti-infection; Cytoskeleton
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/ck-666.html
Purity
99.95
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NCCC1=C(C)NC2=C1C=CC=C2)C3=CC=CC=C3F
Molecular Formula
C18H17FN2O
Molecular Weight
296.34
Precautions
H302
References & Citations
+
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1
Available Sizes
Curated Selection
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