2-PMPA

2-PMPA is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 300 pM.

Product Specifications

CAS Number

[173039-10-6]

Product Name Alternative

2- (Phosphonomethyl) pentanedioic acid

UNSPSC

12352211

Hazard Statement

H315, H319

Target

Carboxypeptidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-PMPA.html

Purity

98.0

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(O)C(CP(O)(O)=O)CCC(O)=O

Molecular Formula

C6H11O7P

Molecular Weight

226.12

Precautions

H315, H319

References & Citations

[1]Rais R, et al. Bioanalytical method for evaluating the pharmacokinetics of the GCP-II inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA) . J Pharm Biomed Anal. 2014 Jan;88:162-9.|[2]Zuo D, et al. Existence of glia mitigated ketamine-induced neurotoxicity in neuron-glia mixed cultures of neonatal rat cortex and the glia-mediated protective effect of 2-PMPA. Neurotoxicology. 2014 Sep;44:218-30.|[3]Baslow MH, et al. 2-PMPA, a NAAG peptidase inhibitor, attenuates magnetic resonance BOLD signals in brain of anesthetized mice: evidence of a link between neuron NAAG release and hyperemia. J Mol Neurosci. 2005;26 (1) :1-15.|[4]Nagel J, et al. Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain-relation to brain concentration. Neuropharmacology. 2006 Dec;51 (7-8) :1163-71.