2-PMPA
2-PMPA is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 300 pM.
Product Specifications
CAS Number
173039-10-6
Product Name Alternative
2- (Phosphonomethyl) pentanedioic acid
UNSPSC
12352211
Hazard Statement
H315, H319
Target
Carboxypeptidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/2-PMPA.html
Purity
98.0
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C(CP(O)(O)=O)CCC(O)=O
Molecular Formula
C6H11O7P
Molecular Weight
226.12
Precautions
H315, H319
References & Citations
[1]Rais R, et al. Bioanalytical method for evaluating the pharmacokinetics of the GCP-II inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA) . J Pharm Biomed Anal. 2014 Jan;88:162-9.|[2]Zuo D, et al. Existence of glia mitigated ketamine-induced neurotoxicity in neuron-glia mixed cultures of neonatal rat cortex and the glia-mediated protective effect of 2-PMPA. Neurotoxicology. 2014 Sep;44:218-30.|[3]Baslow MH, et al. 2-PMPA, a NAAG peptidase inhibitor, attenuates magnetic resonance BOLD signals in brain of anesthetized mice: evidence of a link between neuron NAAG release and hyperemia. J Mol Neurosci. 2005;26 (1) :1-15.|[4]Nagel J, et al. Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain-relation to brain concentration. Neuropharmacology. 2006 Dec;51 (7-8) :1163-71.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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