NSUN2 rabbit pAb
This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA (Leu) (CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011],
Product Specifications
Background
This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA (Leu) (CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2011]
Product Name Alternative
TRNA (cytosine (34) -C (5) ) -methyltransferase (EC 2.1.1.203) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (tRNA (cytosine-5-) -methyltransferase) (tRNA methyltransferase 4 homolog) (hTrm4)
UniProt
Q08J23
Swiss Prot
Q08J23
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human NSUN2 AA range: 658-708
Target
NSUN2
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Molecular Weight
85kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
85kD
Fragment
IgG
Subcellular Location
Nucleus, nucleolus . Cytoplasm . Mitochondrion . Cytoplasm, cytoskeleton, spindle . Secreted, extracellular exosome . Concentrated in the nucleolus during interphase and translocates to the spindle during mitosis as an RNA-protein complex that includes 18S ribosomal RNA (PubMed:19596847) . In testis, localizes to the chromatoid body (By similarity) . .
Other Product Names
TRNA (cytosine (34) -C (5) ) -methyltransferase (EC 2.1.1.203) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (tRNA (cytosine-5-) -methyltransferase) (tRNA methyltransferase 4 homolog) (hTrm4)
Gene ID (Human)
54888
Available Sizes
Curated Selection
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