IL-17RA, Rat (HEK293, His)

IL-17RA (Interleukin 17 receptor A), a receptor for IL-17A and IL-17F, is a type I membrane glycoprotein. It is expressed ubiquitously and exhibits a broad tissue distribution, and plays a role in many inflammatory and autoimmune diseases. IL-17RA is a common co-receptor subunit for other members of the IL-17 family. IL-17RA associates with IL-17RC to form a signaling receptor complex for IL-17A and IL-17F[1][2]. IL-17RA Protein, Rat (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag. It consists of 320 amino acids (M1-P320).

SLRLLDFPAL VCSQEGLNCR VENSTCLDDS WIYPRNLTPS SPKNIYLHLN VSSTQHGDLV PVLHVEWTLQ TDASILYLEG AELSILKLNT NEQLCVKFKF LSKLSNHHKR WRFSFSHFVV DPGQEYEVTV HHLPKPIPDG DPNHKSKTIL VPGCEDTEMK MTTPCVSSGS LWNPNITVET LDTQHLRVDF TLWNESTPYQ ILLESFSGSE NQSCFEDIKQ ISAPGQEEFH QRSNVTFTLS KSGWCCHHLV QVQPFFNSCQ NDCLRHAVTV PCPVISETPV SITAADYIP

[1]Stéphane Nesmond, et al. Characteristic Pattern of IL-17RA, IL-17RB, and IL-17RC in Monocytes/Macrophages and Mast Cells From Patients With Bullous Pemphigoid. Front Immunol. 2019 Sep 11;10:2107.|[2]Xun Lin, et al. IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment. Immunity. 2022 Feb 8;55(2):237-253.e8.|[3]Laura Green, et al. Chronic Candidiasis in Children. Curr Allergy Asthma Rep. 2017 May;17(5):31.