Kushenol C

Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits BACE1 (β-site APP cleaving enzyme 1) with an IC50 of 5.45 μM[1][2].

Product Specifications

CAS Number

[99119-73-0]

UNSPSC

12352005

Target

Beta-secretase

Type

Natural Products

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/kushenol-c.html

Purity

99.58

Solubility

DMSO : 75 mg/mL (ultrasonic)

Smiles

O=C1C(O)=C(C2=CC=C(O)C=C2O)OC3=C(C[C@H](C(C)=C)C/C=C(C)\C)C(O)=CC(O)=C13

Molecular Formula

C25H26O7

Molecular Weight

438.47

References & Citations

[1]Cho BO, et al. In vitro Anti-Inflammatory and Anti-Oxidative Stress Activities of Kushenol C Isolated from the Roots of Sophoraflavescens. Molecules. 2020;25 (8) :1768. Published 2020 Apr 12.|[2]Jung HA, et al. Selective inhibition of prenylated flavonoids from Sophora flavescens against BACE1 and cholinesterases. Am J Chin Med. 2010;38 (2) :415-429.