GSK-3β inhibitor 21
GSK-3β inhibitor 21 (compound 44) is an ATP-competitive GSK-3β inhibitor (IC50=6.06 μM) with anti-amyloid aggregation and tau phosphorylation inhibitory activities. GSK-3β inhibitor 21 can be used in the study of Alzheimer's disease[1].
Product Specifications
UNSPSC
12352005
Target
GSK-3; Tau Protein
Type
Reference compound
Related Pathways
Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gsk-3β-inhibitor-21.html
Smiles
O=C(C1=C(C)NC(NC1C2=CC=C(OC(F)(F)F)C=C2)=O)NC3=CC=C(Cl)C=C3
Molecular Formula
C19H15ClF3N3O3
Molecular Weight
425.79
References & Citations
[1]Sukanya S, et al. Design, synthesis, and biological evaluation of tetrahydropyrimidine analogue as GSK-3β/Aβ aggregation inhibitor and anti-Alzheimer’s agent[J]. Bioorganic Chemistry, 2024: 107811.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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