Molibresib (besylate)
Molibresib besylate (GSK 525762C; I-BET 762 besylate) is a BET bromodomain inhibitor with IC50 of 32.5-42.5 nM.
Product Specifications
CAS Number
[1895049-20-3]
Product Name Alternative
GSK 525762C; I-BET 762 (besylate)
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/molibresib-besylate.html
Purity
97.04
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
ClC1=CC=C(C2=N[C@@H](CC(NCC)=O)C3=NN=C(C)N3C4=CC=C(OC)C=C24)C=C1.O=S(C5=CC=CC=C5)(O)=O
Molecular Formula
C28H28ClN5O5S
Molecular Weight
582.07
References & Citations
[1]Nicodeme E, et al. Suppression of inflammation by a synthetic histone mimic. Nature. 2010 Dec 23;468 (7327) :1119-23.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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