Molibresib (besylate)

Molibresib besylate (GSK 525762C; I-BET 762 besylate) is a BET bromodomain inhibitor with IC50 of 32.5-42.5 nM.

Product Specifications

CAS Number

[1895049-20-3]

Product Name Alternative

GSK 525762C; I-BET 762 (besylate)

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/molibresib-besylate.html

Purity

97.04

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

ClC1=CC=C(C2=N[C@@H](CC(NCC)=O)C3=NN=C(C)N3C4=CC=C(OC)C=C24)C=C1.O=S(C5=CC=CC=C5)(O)=O

Molecular Formula

C28H28ClN5O5S

Molecular Weight

582.07

References & Citations

[1]Nicodeme E, et al. Suppression of inflammation by a synthetic histone mimic. Nature. 2010 Dec 23;468 (7327) :1119-23.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Available Sizes

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