E1231
E1231 is an orally active activator of Sirtuin 1 (SIRT1) (EC50=0.83 μM), to modulate cholesterol and lipid metabolism. E1231 interactes with SIRT1 (KD=9.61 μM) and deacetylated liver X receptor-alpha (LXRα), and increases ATP-binding cassette transporter A1 (ABCA1) expression. E1231 also reduces atherosclerotic plaque development in ApoE-/- mice model. E1231 can be used for research in cholesterol and lipid disorder-related diseases[1].
Product Specifications
CAS Number
1031195-19-3
Product Name Alternative
1-{4-[2- (5-Methylfuran-2-yl) quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/e1231.html
Concentration
10mM
Purity
98.46
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(N1CCN(C(C2=CC(C3=CC=C(C)O3)=NC4=CC=CC=C24)=O)CC1)=O
Molecular Formula
C21H21N3O3
Molecular Weight
363.41
Precautions
H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT1
Available Sizes
Frequently Asked Questions
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